Article

USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3

2021-01-11

Abstract excerpt

Cholangiocarcinoma represents the second most common primary liver malignancy. The incidence rate has constantly increased over the last decades. Cholangiocarcinoma silent nature limits early diagnosis and prevents efficient treatment. Here we demonstrated that USP9X is downregulated in cholangiocarcinoma which contributes to tumorigenesis. The expression of USP9X in cholangiocarcinoma inhibited cell proliferation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f828fe02-1e34-5067-b179-3a1a21114318
DOI: 10.21203/rs.3.rs-141266/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3DOI 10.21203/rs.3.rs-141266/v1Read

Stabilization of EGLN3 by USP9X Contributes to Antineoplastic Function in CholangiocarcinomaSemantic proximity Read

USP8 promotes the tumorigenesis of intrahepatic cholangiocarcinoma via stabilizing OGTSemantic proximity Read

USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1Semantic proximity Read

USP33 Regulates DNA Damage Response and Carcinogenesis Through Deubiquitylating and Stabilising p53Semantic proximity Read

Cellular functions, molecular signalings and therapeutic applications: Translational potential of deubiquitylating enzyme USP9X as a drug target in cancer treatmentSemantic proximity Read

USP13 facilitates a ferroptosis-to-autophagy switch by activation of the NFE2L2/NRF2-SQSTM1/p62-KEAP1 axis dependent on the KRAS signaling pathwaySemantic proximity Read

Roles of USP9X in cellular functions and tumorigenesis (Review)Semantic proximity Read

USP3 : Key deubiquitylation enzyme in human diseasesSemantic proximity Read

Ubiquitin-specific protease 11 serves as a marker of poor prognosis and promotes metastasis in hepatocellular carcinomaSemantic proximity Read

Deubiquitinases in Cancers: Aspects of Proliferation, Metastasis, and ApoptosisSemantic proximity Read

USP14 exhibits high expression levels in hepatocellular carcinoma and plays a crucial role in promoting the growth of liver cancer cells through the HK2/AKT/P62 axisSemantic proximity Read

Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma.Semantic proximity Read