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Article

FGFR1 promotes the stem cell-like phenotype of FGFR1-amplified non-small cell lung cancer cells through the Hedgehog pathway.

Oncotarget - 22 Mar 2016

Ji Wenxiang, Yu Yongfeng, Li Ziming, Wang Guan, Li Fan, Xia Weiliang, Lu Shun

Abstract excerpt

Cancer stem cell-like phenotype is critical for tumor formation and treatment resistance. FGFR1 is found to be amplified in non-small cell lung cancer, particularly in the lung squamous cell cancer (LSCC). Whether FGFR1 contributes to the maintenance of stem cell-like phenotype of FGFR1-amplified lung cancer cells remains elusive. In this study, treatment with FGFR1 inhibitor AZD4547 suppressed the growth of...

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Share to Carcinoma, Non-Small-Cell Lung
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Hedgehog Proteins

Share to Neoplastic Stem Cells

Share to Receptor, Fibroblast Growth Factor, Type 1

Share to Tumor Cells, Cultured

Share to Zinc Finger Protein Gli2

Source

Open in PubMed Open full text

Identifiers

PMID: 26936993
DOI: 10.18632/oncotarget.7701
PMCID: PMC4924774

Genes

FGFR1
GLI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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