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Article

Response to Oxidative Burst-Induced Hypoxia Is Associated With Macrophage Inflammatory Profiles as Revealed by Cellular Genome-Wide Association.

Frontiers in immunology - 1 Jan 2021

Emam Mehdi, Tabatabaei Saeid, Sargolzaei Mehdi, Mallard Bonnie

Abstract excerpt

Background: In mammalian species, hypoxia is a prominent feature of inflammation. The role of hypoxia in regulating macrophage responses via alteration in metabolic pathways is well established. Recently, oxidative burst-induced hypoxia has been shown in murine macrophages after phagocytosis. Despite the available detailed information on the regulation of macrophage function at transcriptomic and epigenomic...

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Source

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Identifiers

PMID: 34220845
DOI: 10.3389/fimmu.2021.688503
PMCID: PMC8253053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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