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Genetic Risk, Muscle Strength, and Incident Stroke: Findings From the UK Biobank Study.

Mayo Clinic proceedings - 1 Jul 2021

Kim Youngwon, Hwang Semi, Sharp Stephen J, Luo Shan, Au Yeung Shiu Lun, Teerlink Craig C

Abstract excerpt

OBJECTIVE: To examine the associations of muscle strength and genetic risk for stroke with stroke incidence. PARTICIPANTS AND METHODS: We included 284,767 white British participants of UK Biobank without genetic relatedness and stroke or myocardial infarction at baseline between March 13, 2006, and October 1, 2010. Genetic risk was assessed with polygenic risk scores, calculated by summing the risk-increasing...

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PMID: 34218855
DOI: 10.1016/j.mayocp.2021.01.034

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