Article
Anaplastic Lymphoma Kinase Overexpression Is Associated with Aggressive Phenotypic Characteristics of Ovarian High-Grade Serous Carcinoma.
The American journal of pathology - 1 Oct 2021
Matsumoto Toshihide, Oda Yusuke, Hasegawa Yoshinori, Hashimura Miki, Oguri Yasuko, Inoue Hisako, Yokoi Ako, Tochimoto Masataka, Nakagawa Mayu, Jiang Zesong, Saegusa Makoto
Abstract excerpt
Deregulated full-length anaplastic lymphoma kinase (ALK) overexpression has been found in some primary solid tumors, but little is known about its role in ovarian high-grade serous carcinoma (HGSC). The current study focused on the functional roles of ALK in HGSC. Cytoplasmic ALK immunoreactivity without chromosomal rearrangement and gene mutations was significantly higher in HGSC compared with non-HGSC-type...
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