SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern.

doi:10.1126/science.abi7994

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Article

SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern.

Science (New York, N.Y.) - 6 Aug 2021

McCallum Matthew, Bassi Jessica, De Marco Anna, Chen Alex, Walls Alexandra C, Di Iulio Julia, Tortorici M Alejandra, Navarro Mary-Jane, Silacci-Fregni Chiara, Saliba Christian, Sprouse Kaitlin R, Agostini Maria, Pinto Dora, Culap Katja, Bianchi Siro, Jaconi Stefano, Cameroni Elisabetta, Bowen John E, Tilles Sasha W, Pizzuto Matteo Samuele, Guastalla Sonja Bernasconi, Bona Giovanni, Pellanda Alessandra Franzetti, Garzoni Christian, Van Voorhis Wesley C, Rosen Laura E, Snell Gyorgy, Telenti Amalio, Virgin Herbert W, Piccoli Luca, Corti Davide, Veesler David

Abstract excerpt

A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429), which was originally detected in California, carries spike glycoprotein mutations S13I in the signal peptide, W152C in the N-terminal domain (NTD), and L452R in the receptor-binding domain (RBD). Plasma from individuals vaccinated with a Wuhan-1 isolate-based messenger RNA vaccine or from convalescent individuals exhibited neutralizing titers that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34210893
DOI: 10.1126/science.abi7994
PMCID: PMC9835956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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