Article
CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis.
International journal of molecular sciences - 29 Jun 2021
Loreth Desiree, Schuette Moritz, Zinke Jenny, Mohme Malte, Piffko Andras, Schneegans Svenja, Stadler Julia, Janning Melanie, Loges Sonja, Joosse Simon A, Lamszus Katrin, Westphal Manfred, Müller Volkmar, Glatzel Markus, Matschke Jakob, Gebhardt Christoffer, Schneider Stefan W, Belczacka Iwona, Volkmer Beate, Greinert Rüdiger, Yaspo Marie-Laure, Harter Patrick N, Pantel Klaus, Wikman Harriet
Abstract excerpt
Up to 40% of advance lung, melanoma and breast cancer patients suffer from brain metastases (BM) with increasing incidence. Here, we assessed whether circulating tumor cells (CTCs) in peripheral blood can serve as a disease surrogate, focusing on CD44 and CD74 expression as prognostic markers for BM. We show that a size-based microfluidic approach in combination with a semi-automated cell recognition system are...
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