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Article

Transcriptomic Landscape of Lower Grade Glioma Based on Age-Related Non-Silent Somatic Mutations.

Current oncology (Toronto, Ont.) - 19 Jun 2021

Park YoungJoon, Park JeongMan, Ahn Ju Won, Sim Jeong Min, Kang Su Jung, Kim Suwan, Hwang So Jung, Han Song-Hee, Sung Kyoung Su, Lim Jaejoon

Abstract excerpt

Glioma accounts for 80% of all malignant brain tumours and is the most common adult primary brain tumour. Age is an important factor affecting the development of cancer, as somatic mutations accumulate with age. Here, we aimed to analyse the significance of age-dependent non-silent somatic mutations in glioma prognosis. Histological tumour grade depends on age at diagnosis in patients with IDH1, TP53, ATRX, and...

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Identifiers

PMID: 34205437
DOI: 10.3390/curroncol28030210
PMCID: PMC8293196

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