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Article

Genetic variant in 3' untranslated region of the mouse pycard gene regulates inflammasome activity.

eLife - 1 Jul 2021

Ritchey Brian, Hai Qimin, Han Juying, Barnard John, Smith Jonathan D

Abstract excerpt

Quantitative trait locus mapping for interleukin-1β release after inflammasome priming and activation was performed on bone-marrow-derived macrophages (BMDM) from an AKRxDBA/2 mouse strain intercross. The strongest associated locus mapped very close to the Pycard gene on chromosome 7, which codes for the inflammasome adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC). The DBA/2 and...

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Identifiers

PMID: 34197316
DOI: 10.7554/eLife.68203
PMCID: PMC8248980

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