Article
Prevalence and molecular spectrum of α- and β-globin gene mutations in Hainan, China.
International journal of hematology - 1 Sept 2021
Wang Zhen, Sun Wenye, Chen Huaye, Zhang Yongfang, Wang Fei, Chen Hongjian, Zhou Yao, Huang Yanhua, Zhou XiXi, Li Qi, Ma Yanlin
Abstract excerpt
This study investigated prenatal diagnosis of α-thalassemia and β-thalassemia in 3049 families in 18 regions of Hainan Province. Molecular diagnosis was performed in 3049 couples with thalassemia in Hainan Province. Genomic DNA was extracted from peripheral blood of the couples and villus, amniotic fluid, or cord blood of fetuses. DNA-based diagnosis was performed using polymerase chain reaction. The most...
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