Article
Molecular spectrum of α- and β-globin gene mutations detected in the population of Guangxi Zhuang Autonomous Region, People's Republic of China.
Hemoglobin - 1 Jan 2011
Zheng Chen-Guang, Liu Ming, Du Juan, Chen Ke, Yang Yige, Yang Ze
Abstract excerpt
We studied 6,023 individuals diagnosed with anemia on the basis of hematological examinations. The study showed that the frequency of α-thalassemia (α-thal) carriers was 26.9% and β-thal carriers comprised 19.9% of the population of Guangxi Zhuang Autonomous Region, People's Republic of China (PCR). The diagnosed α-thal anomalies were related to six gene mutations and 16 genotypes, whereas the β-thal were related...
Topics
- Alleles
- China
- Codon
- Gene Frequency
- Genetic Association Studies
- Genotype
- Hematologic Tests
- Humans
- Point Mutation
- Population Surveillance
- Risk Assessment
- Severity of Illness Index
- alpha-Globins
- alpha-Thalassemia
- beta-Globins
- beta-Thalassemia