Article
The prevalence and molecular spectrum of α- and β-globin gene mutations in 14,332 families of Guangdong Province, China.
PloS one - 1 Jan 2014
Yin Aihua, Li Bing, Luo Mingyong, Xu Longchang, Wu Li, Zhang Liang, Ma Yuanzhu, Chen Tingting, Gao Shuang, Liang Juqing, Guo Hao, Qin Danqing, Wang Jicheng, Yuan Tenglong, Wang Yixia, Huang Wei-wei, He Wen-Fei, Zhang Yanxia, Liu Chang, Xia Sujian, Chen Qingshan, Zhao Qingguo, Zhang Xiaozhuang
Abstract excerpt
OBJECTIVE: To reveal the familial prevalence and molecular variation of α- and β-globin gene mutations in Guangdong Province. METHODS: A total of 40,808 blood samples from 14,332 families were obtained and analyzed for both hematological and molecular parameters. RESULTS: A high prevalence of α- and β-globin gene mutations was found. Overall, 17.70% of pregnant women, 15.94% of their husbands, 16.03% of neonates,...
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