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Article

Unraveling the MRI-Based Microstructural Signatures Behind Primary Progressive and Relapsing-Remitting Multiple Sclerosis Phenotypes.

Journal of magnetic resonance imaging : JMRI - 1 Jan 2022

Boscolo Galazzo Ilaria, Brusini Lorenza, Akinci Muge, Cruciani Federica, Pitteri Marco, Ziccardi Stefano, Bajrami Albulena, Castellaro Marco, Salih Ahmed M A, Pizzini Francesca B, Jovicich Jorge, Calabrese Massimiliano, Menegaz Gloria

Abstract excerpt

BACKGROUND: The mechanisms driving primary progressive and relapsing-remitting multiple sclerosis (PPMS/RRMS) phenotypes are unknown. Magnetic resonance imaging (MRI) studies support the involvement of gray matter (GM) in the degeneration, highlighting its damage as an early feature of both phenotypes. However, the role of GM microstructure is unclear, calling for new methods for its decryption. PURPOSE: To...

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PMID: 34189804
DOI: 10.1002/jmri.27806
PMCID: PMC9290631

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