Article

MPRAGE-derived quantitative T <sub>1</sub> mapping to assess diffuse white matter alterations in multiple sclerosis

2026-05-10

Abstract excerpt

<h4>Background</h4> Multiple sclerosis (MS) is characterized by focal white matter (WM) lesions, but subtle damage also occurs in normal-appearing white matter (NAWM). We developed a method to generate quantitative T 1 maps from MPRAGE (Magnetization Prepared Rapid Gradient Echo) images and evaluated its ability to detect NAWM abnormalities across different MS phenotypes. <h4>Methods</h4> T 1 maps were derive...

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Literature Corpus work: 12bcb264-6242-56dc-a870-f88b933da928
DOI: 10.64898/2026.05.04.26351019

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