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Article

Progressive iron accumulation across multiple sclerosis phenotypes revealed by sparse classification of deep gray matter.

Journal of magnetic resonance imaging : JMRI - 1 Nov 2017

Elkady Ahmed M, Cobzas Dana, Sun Hongfu, Blevins Gregg, Wilman Alan H

Abstract excerpt

PURPOSE: To create an automated framework for localized analysis of deep gray matter (DGM) iron accumulation and demyelination using sparse classification by combining quantitative susceptibility (QS) and transverse relaxation rate (R2*) maps, for evaluation of DGM in multiple sclerosis (MS) phenotypes relative to healthy controls. MATERIALS AND METHODS: R2*/QS maps were computed using a 4.7T 10-echo gradient...

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PMID: 28301067
DOI: 10.1002/jmri.25682

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