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Article

Markers with low GenTrain scores can generate spurious signals in genome-wide scans for transmission ratio distortion.

Animal genetics - 1 Oct 2021

Luigi-Sierra María Gracia, Casellas Joaquim, Martínez Amparo, Vicente Delgado Juan, Fernández Álvarez Javier, Such Francesc Xavier, Jordana Jordi, Amills Marcel

Abstract excerpt

Transmission ratio distortion (TRD) is the preferential transmission of one specific allele to offspring at the expense of the other. The existence of TRD is mostly explained by the segregation of genetic variants with deleterious effects on the developmental processes that go from the formation of gametes to fecundation and birth. A few years ago, a statistical methodology was implemented in order to detect TRD...

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PMID: 34189737
DOI: 10.1111/age.13107

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