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Article

Assembly of higher-order SMN oligomers is essential for metazoan viability and requires an exposed structural motif present in the YG zipper dimer.

Nucleic acids research - 21 Jul 2021

Gupta Kushol, Wen Ying, Ninan Nisha S, Raimer Amanda C, Sharp Robert, Spring Ashlyn M, Sarachan Kathryn L, Johnson Meghan C, Van Duyne Gregory D, Matera A Gregory

Abstract excerpt

Protein oligomerization is one mechanism by which homogenous solutions can separate into distinct liquid phases, enabling assembly of membraneless organelles. Survival Motor Neuron (SMN) is the eponymous component of a large macromolecular complex that chaperones biogenesis of eukaryotic ribonucleoproteins and localizes to distinct membraneless organelles in both the nucleus and cytoplasm. SMN forms the...

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Identifiers

PMID: 34181727
DOI: 10.1093/nar/gkab508
PMCID: PMC8287954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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