Article

Self-oligomerization regulates stability of Survival Motor Neuron (SMN) protein isoforms by sequestering an SCF <sup>Slmb</sup> degron

2016-09-30

Abstract excerpt

Spinal muscular atrophy (SMA) is caused by homozygous mutations in human SMN1 . Expression of a duplicate gene ( SMN2 ) primarily results in skipping of exon 7 and production of an unstable protein isoform, SMNΔ7. Although SMN2 exon skipping is the principal contributor to SMA severity, mechanisms governing stability of SMN isoforms are poorly understood. We used a Drosophila model system and label-free proteo...

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Literature Corpus work: f68c62d2-fb50-5a05-9653-a0e0d43d7a3c
DOI: 10.1101/078337

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