Dissecting the Fitness Costs of Complex Mutations.

Abstract excerpt

The fitness cost of complex pleiotropic mutations is generally difficult to assess. On the one hand, it is necessary to identify which molecular properties are directly altered by the mutation. On the other, this alteration modifies the activity of many genetic targets with uncertain consequences. Here, we examine the possibility of addressing these challenges by identifying unique predictors of these costs. To...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA-Directed RNA Polymerases
• Share to Escherichia coli
• Share to Mutation