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Repeat to gene expression ratios in leukemic blast cells can stratify risk prediction in acute myeloid leukemia

26 Jun 2021

Abstract excerpt

BACKGROUND: Repeat elements constitute a large proportion of the human genome and recent evidence indicates that repeat element expression has functional roles in both physiological and pathological states. Specifically for cancer, transcription of endogenous retrotransposons is often suppressed to attenuate an anti-tumor immune response, whereas aberrant expression of heterochromatin-derived satellite RNA has...

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PMID: 34174884
DOI: 10.1186/s12920-021-01003-z

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