Article
Context-dependent modulation of aggressiveness of pediatric tumors by individual oncogenic RAS isoforms.
Oncogene - 1 Aug 2021
Bauer Julia, Cuvelier Nicole, Ragab Nada, Simon-Keller Katja, Nitzki Frauke, Geyer Natalie, Botermann Dominik S, Elmer Dominik P, Rosenberger Albert, Rando Thomas A, Biressi Stefano, Fagin James A, Saur Dieter, Dullin Christian, Schildhaus Hans-Ulrich, Schulz-Schaeffer Walter, Aberger Fritz, Uhmann Anja, Hahn Heidi
Abstract excerpt
A prototypic pediatric cancer that frequently shows activation of RAS signaling is embryonal rhabdomyosarcoma (ERMS). ERMS also show aberrant Hedgehog (HH)/GLI signaling activity and can be driven by germline mutations in this pathway. We show, that in ERMS cell lines derived from sporadic tumors i.e. from tumors not caused by an inherited genetic variant, HH/GLI signaling plays a subordinate role, because...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.