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Article

Evaluation of vanillin as a probe drug for aldehyde oxidase and phenotyping for its activity in a Western Indian Cohort.

Indian journal of pharmacology - 1 Jan 2000

Subash Sandhya, Gogtay Nithya J, Iyer Krishna R, Gandhe Prajakta, Budania Ritu, Thatte Urmila M

Abstract excerpt

BACKGROUND: Aldehyde oxidase (AO), a molybdoflavoenzyme, is emerging as a key player in drug discovery and metabolism. Despite having several known substrates, there are no validated probes reported for studying the activity of AO in vivo. Vanillin (4-hydroxy 3-methoxy benzaldehyde) is an excellent substrate of AO, in vitro. In the present study, vanillin has been validated as an in vivo probe for AO....

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Identifiers

PMID: 34169906
DOI: 10.4103/ijp.IJP_463_18
PMCID: PMC8262417

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