Article
A new sensitive and fast assay for the detection of EGFR mutations in liquid biopsies.
PloS one - 1 Jan 2021
Jensen Steffen Grann, Epistolio Samantha, Madsen Cesilie Lind, Kyneb Majbritt Hauge, Riva Alice, Paganotti Alessia, Barizzi Jessica, Petersen Rasmus Koefoed, Børgesen Michael, Molinari Francesca, Boldorini Renzo, Lorenzen Jan, Sørensen Erik, Christensen Ulf Bech, Høgdall Estrid, Frattini Milo
Abstract excerpt
BACKGROUND: A major perspective for the use of circulating tumor DNA (ctDNA) in the clinical setting of non-small cell lung cancer (NSCLC) is expected as predictive factor for resistance and response to EGFR TKI therapy and, especially, as a non-invasive alternative to tissue biopsy. However, ctDNA is both highly fragmented and mostly low concentrated in plasma and serum. On this basis, it is important to use a...
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