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Article

Analytical and Clinical Validation of a Highly Sensitive NGS-Based ctDNA Assay with Real-World Concordance in Non-Small Cell Lung Cancer.

Cancer research and treatment - 1 Jul 2024

Yi Hanbaek, Youk Jeonghwan, Lim Yoojoo, Roh Hanseong, Kyung Dongsoo, Kim Hwang-Phill, Bang Duhee, Keam Bhumsuk, Kim Tae-Min, Kim Miso, Kim Dong-Wan, Kim Tae-You

Abstract excerpt

PURPOSE: There have been needs to improve the sensitivity of liquid biopsy. This report aims to report the analytical and clinical validation of a next-generation sequencing (NGS)-based circulating tumor DNA (ctDNA) assay. MATERIALS AND METHODS: Analytical validation was conducted in vitro by evaluating the limit of detection (LOD), precision, and specificity for various genomic aberrations. The real-world...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38186238
DOI: 10.4143/crt.2023.1294
PMCID: PMC11261189

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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