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Article

Enrichment of mutated DNA enables ultra-sensitive ctDNA detection in NSCLC using shallow targeted sequencing.

Scientific reports - 13 Jun 2026

Labrousse Paul, Russell Hugh, Stetson Daniel, Powalowska-Pickton Paulina K, Anton Katarzyna A, Litovchenko Maria, Lowy-Gallego Ernesto, Lovell Amy, Hackinger Sophie, Stolarek-Januszkiewicz Magdalena, Balmforth Barnaby W, Hadfield James

Abstract excerpt

Liquid biopsy assays using next-generation sequencing have emerged as a promising tool in cancer diagnostics to aid detection of minimal residual disease (MRD) and treatment monitoring. A key concern is the trade-off between sensitivity and sequencing depth, with ultra-sensitive techniques suffering from high costs. To this end, we sought to evaluate the analytical performance of Enspyre, a novel ctDNA enrichment...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42288656
DOI: 10.1038/s41598-026-57421-5
PMCID: PMC13522495

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