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Article

The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide.

Pharmacogenomics - 1 Feb 2009

Pawlik Andrzej, Herczynska Magdalena, Kurzawski Mateusz, Safranow Krzysztof, Dziedziejko Violetta, Drozdzik Marek

Abstract excerpt

OBJECTIVE: Leflunomide is an isoxazole derivative structurally and functionally unrelated to other known immunomodulatory drugs. The main molecular target of leflunomide is dihydroorotate dehydrogenase (DHODH), a key enzyme of de novo pyrimidine synthesis. The human DHODH gene sequence is highly...

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Source

Identifiers

PMID: 19207032
DOI: 10.2217/14622416.10.2.303

Genes

DHODH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19207032-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide.PMID 19207032Read ↗

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