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Article

Intravital Imaging of Candida albicans Identifies Differential In Vitro and In Vivo Filamentation Phenotypes for Transcription Factor Deletion Mutants.

mSphere - 30 Jun 2021

Wakade Rohan S, Huang Manning, Mitchell Aaron P, Wellington Melanie, Krysan Damian J

Abstract excerpt

Candida albicans is an important cause of human fungal infections. A widely studied virulence trait of C. albicans is its ability to undergo filamentation to hyphae and pseudohyphae. Although yeast, pseudohyphae, and hyphae are present in pathological samples of infected mammalian tissue, it has been challenging to characterize the role of regulatory networks and specific genes during in vivo filamentation. In...

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Identifiers

PMID: 34160243
DOI: 10.1128/mSphere.00436-21
PMCID: PMC8265662

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