Expression levels of a filament-specific transcriptional regulator are sufficient to determine <i>Candida albicans</i> morphology and virulence

Abstract excerpt

Candida albicans, the major human fungal pathogen, undergoes a reversible morphological transition from single yeast cells to pseudohyphal and hyphal filaments (elongated cells attached end-to-end). Because typical C. albicans infections contain a mixture of these morphologies it has, for many years, been difficult to assess the relative contribution of each form to virulence. In addition, the regulatory...

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