Article
DAGM: A novel modelling framework to assess the risk of HER2-negative breast cancer based on germline rare coding mutations.
EBioMedicine - 1 Jul 2021
Yang Mei, Fan Yanhui, Wu Zhi-Yong, Gu Jin, Feng Zhendong, Zhang Qiangzu, Han Shunhua, Zhang Zhonghai, Li Xu, Hsueh Yi-Ching, Ni Yanxiang, Li Xiaoling, Li Jieqing, Hu Meixia, Li Weiping, Gao Hongfei, Yang Ciqiu, Zhang Chunming, Zhang Liulu, Zhu Teng, Cheng Minyi, Ji Fei, Xu Juntao, Cui Hening, Tan Guangming, Zhang Michael Q, Liang Changhong, Liu Zaiyi, Song You-Qiang, Niu Gang, Wang Kun
Abstract excerpt
BACKGROUND: Breast cancers can be divided into HER2-negative and HER2-positive subtypes according to different status of HER2 gene. Despite extensive studies connecting germline mutations with possible risk of HER2-negative breast cancer, the main category of breast cancer, it remains challenging to obtain accurate risk assessment and to understand the potential underlying mechanisms. METHODS: We developed a...
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