Mutagen-mediated enhancement of HIV-1 replication in persistently infected cells.

doi:10.1016/j.virol.2011.12.016

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Article

Mutagen-mediated enhancement of HIV-1 replication in persistently infected cells.

Virology - 15 Mar 2012

Sánchez-Jiménez Carmen, Olivares Isabel, de Ávila Lucas Ana Isabel, Toledano Víctor, Gutiérrez-Rivas Mónica, Lorenzo-Redondo Ramón, Grande-Pérez Ana, Domingo Esteban, López-Galíndez Cecilio

Abstract excerpt

Lethal mutagenesis, a new antiviral strategy to extinguish virus through elevated mutation rates, was explored in H61-D cells an HIV-1 persistently infected lymphoid cell line. Three mutagenic agents: 5-hydroxy-2(')-deoxycytidine (5-OHdC), 5-fluorouracil (5-FU) and 2,2(')-difluoro-2(')-deoxycytidine (gemcitabine) were used. After 54 passages, treatments with 5-FU and gemcitabine reduced virus infectivity, p24 and...

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Identifiers

PMID: 22265575
DOI: 10.1016/j.virol.2011.12.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.