Article
Mutations in apoptosis genes: a pathogenetic factor for human disease.
Mutation research - 1 Jul 2001
Müllauer L, Gruber P, Sebinger D, Buch J, Wohlfart S, Chott A
Abstract excerpt
Cell death by apoptosis is exerted by the coordinated action of many different gene products. Mutations in some of them, acting at different levels in the apoptosis process, have been identified as cause or contributing factor for human diseases. Defects in the transmembrane tumor necrosis factor receptor 1 (TNF-R1) lead to the development of familial periodic fever syndromes. Mutations in the homologous receptor...
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