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Article

Epigenetic down‐regulation of microRNA‐126 in scleroderma endothelial cells is associated with impaired responses to VEGF and defective angiogenesis

17 Jun 2021

Abstract excerpt

Impaired angiogenesis in scleroderma (SSc) is a critical component of SSc pathology. MicroRNA-126 (miR-126) is expressed in endothelial cells (MVECs) where it regulates VEGF responses by repressing the negative regulators of VEGF, including the sprouty-related protein-1 (SPRED1), and phosphoinositide-3 kinase regulatory subunit 2 (PIK3R2). MVECs were isolated from SSc skin and matched subjects (n = 6). MiR-126...

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PMID: 34137496
DOI: 10.1111/jcmm.16727

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