Article
Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions.
Arthritis and rheumatism - 1 Nov 2008
Avouac J, Wipff J, Goldman O, Ruiz B, Couraud P O, Chiocchia G, Kahan A, Boileau C, Uzan G, Allanore Y
Abstract excerpt
OBJECTIVE: To assess angiogenesis and explore the expression and regulation of vascular endothelial growth factor (VEGF), VEGF receptor 1 (VEGFR-1), and VEGFR-2, the leading mediators of angiogenesis, in SSc patients and controls. METHODS: Late-outgrowth endothelial progenitor cells (EPCs), isolated from the peripheral blood of systemic sclerosis (SSc) patients and controls, and human umbilical vein endothelial...
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