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Article

Prolonged parent-child separation and pain in adolescence: The role of HPA-axis genetic variations.

Journal of affective disorders - 1 Sept 2021

Chen Xing-Xing, Xu Luo-Piao, Zeng Chen-Chen, Zhang Xing-Yan, Tao Fang-Biao, Sun Ying

Abstract excerpt

BACKGROUND: Increasing evidence has demonstrated that childhood adversity was a predictor of pain and hypothalamic-pituitary-adrenal (HPA) axis genetic variation is associated with pain risk. This study aims to explore possible effects of prolonged childhood separation from parents and HPA polygenic risk score (PRS) on pain among adolescents in rural China. METHOD: We used data from 219 adolescents in rural area...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34134023
DOI: 10.1016/j.jad.2021.05.092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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