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Article

Clinical and experimental phenotype of azole-resistant Aspergillus fumigatus with a HapE splice site mutation: a case report.

BMC infectious diseases - 14 Jun 2021

Ito Yuya, Takazono Takahiro, Koga Satoru, Nakano Yuichiro, Ashizawa Nobuyuki, Hirayama Tatsuro, Tashiro Masato, Saijo Tomomi, Yamamoto Kazuko, Imamura Yoshifumi, Miyazaki Taiga, Yanagihara Katsunori, Izumikawa Koichi, Mukae Hiroshi

Abstract excerpt

BACKGROUND: The recent increase in cases of azole-resistant Aspergillus fumigatus (ARAf) infections is a major clinical concern owing to its treatment limitations. Patient-derived ARAf occurs after prolonged azole treatment in patients with aspergillosis and involves various cyp51A point mutations or non-cyp51A mutations. The prognosis of patients with chronic pulmonary aspergillosis (CPA) with patient-derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34126952
DOI: 10.1186/s12879-021-06279-1
PMCID: PMC8204526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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