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Article

Potent RBD-specific neutralizing rabbit monoclonal antibodies recognize emerging SARS-CoV-2 variants elicited by DNA prime-protein boost vaccination.

Emerging microbes & infections - 1 Dec 2021

Chen Yuxin, Zhu Liguo, Huang Weijin, Tong Xin, Wu Hai, Tao Yue, Tong Bei, Huang Haibin, Chen Jiachen, Zhao Xiangan, Lou Yang, Wu Chao

Abstract excerpt

Global concerns arose as the emerged and rapidly spreading SARS-CoV-2 variants might escape host immunity induced by vaccination. In this study, a heterologous prime-boost immunization strategy for COVID-19 was designed to prime with a DNA vaccine encoding wild type (WT) spike protein receptor-binding domain (RBD) followed by S1 protein-based vaccine in rabbits. Four vaccine-elicited rabbit monoclonal antibodies...

Read the complete abstract on PubMed

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Share to Antibodies, Neutralizing
Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunization, Secondary

Share to Spike Glycoprotein, Coronavirus

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Share to Vaccines, DNA

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Source

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Identifiers

PMID: 34120577
DOI: 10.1080/22221751.2021.1942227
PMCID: PMC8274519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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