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Article

Functional analysis of cysteine residues of the Hok/Gef type I toxins in Escherichia coli.

FEMS microbiology letters - 22 Jun 2021

Wilmaerts Dorien, De Loose Pieter-Jan, Vercauteren Silke, De Smedt Sandrien, Verstraeten Natalie, Michiels Jan

Abstract excerpt

The Hok/Gef family consists of structurally similar, single-span membrane peptides that all contain a positively charged N-terminal domain, an α-helix and a periplasmic C-terminal domain. Hok/Gef peptides have previously been described to play distinct physiological roles. Indeed, while HokB has been implicated in bacterial persistence, other members of the Hok/Gef family are known to induce cell lysis. However,...

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Identifiers

PMID: 34114031
DOI: 10.1093/femsle/fnab069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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