SOX9 inactivation affects the proliferation and differentiation of human lung organoids

Abstract excerpt

Abstract Background The regulation of the transcription factor sex-determining region Y-box transcription factor 9 (SOX9) in lung development has been described in mouse, but the same principles apply to human lung development is unknown due to a lack of appropriate experimental approaches and models. Methods Here, we used gene editing technology to inactivate SOX9 in human embryonic stem cells that were then...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Developmental Biology and Gene Regulation
• Share to Neonatal Respiratory Health Research
• Share to Renal and related cancers