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Article

Sox2 regulates the emergence of lung basal cells by directly activating the transcription of Trp63.

American journal of respiratory cell and molecular biology - 1 Aug 2014

Ochieng Joshua K, Schilders Kim, Kool Heleen, Boerema-De Munck Anne, Buscop-Van Kempen Marjon, Gontan Cristina, Smits Ron, Grosveld Frank G, Wijnen Rene M H, Tibboel Dick, Rottier Robbert J

Abstract excerpt

Lung development is determined by the coordinated expression of several key genes. Previously, we and others have shown the importance of the sex determining region Y-box 2 (Sox2) gene in lung development. Transgenic expression of Sox2 during lung development resulted in cystic airways, and here we show that modulating the timing of ectopic Sox2 expression in the branching regions of the developing lung results...

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Source

Identifiers

PMID: 24669837
DOI: 10.1165/rcmb.2013-0419OC

Genes

SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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