Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The triterpenoid ursolic acid ameliorates stress in Caenorhabditis elegans by affecting the depression-associated genes skn-1 and prdx2.

Phytomedicine : international journal of phytotherapy and phytopharmacology - 15 Jul 2021

Naß Janine, Abdelfatah Sara, Efferth Thomas

Abstract excerpt

INTRODUCTION: Depression is one of the leading causes of death worldwide. Lower antioxidant concentrations and increased oxidative stress levels contribute to the development of depression. Effective and tolerable medications are urgently needed. Nrf2 and PRDX2 are promising targets in the treatment of oxidative stress and, therefore, promising for the development of novel antidepressants. Ursolic acid (UA), a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents
Share to Antioxidants

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Depression

Share to Molecular Docking Simulation

Share to Peroxiredoxins

Share to Protective Agents

Share to Triterpenes

Source

Identifiers

PMID: 34111615
DOI: 10.1016/j.phymed.2021.153598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The triterpenoid ursolic acid ameliorates stress in Caenorhabditis elegans by affecting the depression-associated genes skn-1 and prdx2.PMID 34111615Read ↗

Ursolic acid enhances stress resistance, reduces ROS accumulation and prolongs life span in C. elegans serotonin-deficient mutants.Semantic proximity Read ↗

Ursolic acid ameliorates stress and reactive oxygen species in C. elegans knockout mutants by the dopamine Dop1 and Dop3 receptors.Semantic proximity Read ↗

Rosmarinic acid ameliorated oxidative stress, neuronal injuries, and mitochondrial dysfunctions mediated by polyglutamine and ɑ-synuclein in Caenorhabditis elegans modelsSemantic proximity Read ↗

Increased Stress Resistance and Lifespan in Chaenorhabditis elegans Wildtype and Knockout Mutants-Implications for Depression Treatment by Medicinal Herbs.Semantic proximity Read ↗

Oxidation and Antioxidation of Natural Products in the Model Organism Caenorhabditis elegansSemantic proximity Read ↗

<em>Caenorhabditis elegans</em> as a Model for Studying Nrf2/SKN-1 Activation in Alzheimer’s Disease: Plant Bioactive Compounds and Therapeutic TranslationSemantic proximity Read ↗

Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan ofCaenorhabditis elegansvia DAF-16 and HSF-1Semantic proximity Read ↗

The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans.Semantic proximity Read ↗

Trigonelline Extends the Lifespan of C. Elegans and Delays the Progression of Age‐Related Diseases by Activating AMPK, DAF‐16, and HSF‐1Semantic proximity Read ↗

ROS-Mediated Nematocidal Activity and Reproductive Toxicity of Herbal Extracts in <em>Caenorhabditis elegans</em>Semantic proximity Read ↗

Benzimidazole derivative M084 extends the lifespan of Caenorhabditis elegans in a DAF-16/FOXO-dependent way.Semantic proximity Read ↗

Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress toleranceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.