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Associations between major psychiatric disorder polygenic risk scores and blood-based markers in UK biobank.

Brain, behavior, and immunity - 1 Oct 2021

Sewell Michael D E, Jiménez-Sánchez Lorena, Shen Xueyi, Edmondson-Stait Amelia J, Green Claire, Adams Mark J, Rifai Olivia M, McIntosh Andrew M, Lyall Donald M, Whalley Heather C, Lawrie Stephen M

Abstract excerpt

Major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD) have both shared and discrete genetic risk factors, and are associated with peripheral abnormalities. The relationships between such genetic architectures and blood-based markers are, however, unclear. We investigated relationships between polygenic risk scores (PRS) for these disorders and peripheral markers in the UK Biobank cohort....

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PMID: 34107350
DOI: 10.1016/j.bbi.2021.06.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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