Article
HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults.
Nature medicine - 1 Jun 2021
Dharan Nila J, Yeh Paul, Bloch Mark, Yeung Miriam M, Baker David, Guinto Jerick, Roth Norman, Ftouni Sarah, Ognenovska Katherine, Smith Don, Hoy Jennifer F, Woolley Ian, Pell Catherine, Templeton David J, Fraser Neil, Rose Nectarios, Hutchinson Jolie, Petoumenos Kathy, Dawson Sarah-Jane, Polizzotto Mark N, Dawson Mark A
Abstract excerpt
People with human immunodeficiency virus (HIV) have higher rates of certain comorbidities, particularly cardiovascular disease and cancer, than people without HIV1-5. In view of observations that somatic mutations associated with age-related clonal hematopoiesis (CH) are linked to similar comorbidities in the general population6-10, we hypothesized that CH may be more prevalent in people with HIV. To address this...
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