Article
Effect of Clonal Hematopoiesis on Cardiovascular Disease in People Living with HIV.
Experimental hematology - 1 Oct 2022
Wiley Brian, Parsons Tyler M, Burkart Samantha, Young Andrew L, Erlandson Kristine M, Tassiopoulos Katherine K, Wu Kunling, Gurnett Christina, Presti Rachel M, Bolton Kelly L, Challen Grant A
Abstract excerpt
Hematopoietic stem cells (HSCs) with age-associated somatic mutations that disproportionally contribute to hematopoiesis generate the condition known as clonal hematopoiesis (CH). While CH conveys increased risk of hematologic cancer, there is also strong association between CH and cardiovascular disease (CVD). Accumulating evidence suggests that inflammation mechanistically links CH to CVD, and we hypothesized...
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