Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LncRNA TUG1/miR-29c-3p/SIRT1 axis regulates endoplasmic reticulum stress-mediated renal epithelial cells injury in diabetic nephropathy model in vitro

7 Jun 2021

Abstract excerpt

Long non-coding RNAs (lncRNAs) are important regulators in diabetic nephropathy. In this study, we investigated the potential role of lncRNA TUG1 in regulating endoplasmic reticulum stress (ERS)-mediated apoptosis in high glucose induced renal tubular epithelial cells. Human renal tubular epithelial cell line HK-2 was challenged with high glucose following transfection with lncRNA TUG1, miR-29c-3p mimics or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer-related molecular mechanisms research
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34097717
DOI: 10.1371/journal.pone.0252761

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LncRNA TUG1/miR-29c-3p/SIRT1 axis regulates endoplasmic reticulum stress-mediated renal epithelial cells injury in diabetic nephropathy model in vitroPMID 34097717Read ↗

Inhibition of the lncRNA 585189 prevents podocyte injury and mitochondria dysfunction by promoting hnRNP A1 and SIRT1 in diabetic nephropathySemantic proximity Read ↗

microRNA-20b contributes to high glucose-induced podocyte apoptosis by targeting SIRT7Semantic proximity Read ↗

Correlation Between Polymorphisms of the SIRT1 Gene microRNA Target Sites and Diabetic Nephropathy.Semantic proximity Read ↗

Key circRNAs, lncRNAs, and mRNAs of ShenQi Compound in protecting vascular endothelial cells from high glucose identified by whole transcriptome sequencingSemantic proximity Read ↗

MiR-770-5p facilitates podocyte apoptosis and inflammation in diabetic nephropathy by targeting TIMP3Semantic proximity Read ↗

LncRNA MALAT1 aggravates high glucose-induced renal tubular epithelial injury via activating LIN28A and the Nox4/AMPK/mTOR signaling axisSemantic proximity Read ↗

Rosuvastatin Ameliorates High Glucose-induced Endothelial Cell Dysfunction through HIF-1 ActivationSemantic proximity Read ↗

Comprehensive circRNA Expression Profile and Transcriptomics-Based Molecular Pathway Analysis of the Sodium-Glucose Co-Transporter-2 Inhibitor Dapagliflozin in Diabetic Tubular Epithelial CellsSemantic proximity Read ↗

APOL1 risk variants cause podocytes injury through enhancing endoplasmic reticulum stress.Semantic proximity Read ↗

Knockdown of lncRNA PVT1 alleviates high glucose-induced proliferation and fibrosis in human mesangial cells by miR-23b-3p/WT1 axisSemantic proximity Read ↗

Sacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney diseaseSemantic proximity Read ↗

MicroRNA regulation of the proliferation and apoptosis of Leydig cells in diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.