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Knockdown of lncRNA PVT1 alleviates high glucose-induced proliferation and fibrosis in human mesangial cells by miR-23b-3p/WT1 axis

15 Apr 2020

Abstract excerpt

Abstract Background Diabetic nephropathy (DN) is a severe complication of diabetes with type 1 and 2. Long non-coding RNAs (lncRNAs) are being found to be involved in the DN pathogenesis. In this study, we aimed to further explore the effect and underlying mechanism of plasmacytoma variant translocation 1 (PVT1) in DN pathogenesis. Methods The expression levels of PVT1, miR-23b-3p, and Wilms tumor protein 1 (WT1)...

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PMID: 32322310
DOI: 10.1186/s13098-020-00539-x

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