Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Downregulation of THRSP Promotes Hepatocellular Carcinoma Progression by Triggering ZEB1 Transcription in an ERK-dependent Manner

1 Jan 2021

Abstract excerpt

Background: Hepatocellular carcinoma (HCC) is a major leading cause of cancer mortality worldwide. Thyroid hormone responsive (THRSP) gene is primarily known for regulating responses to thyroid hormones, but its expression has been correlated with differential outcomes in some cancers. To date, however, its role in the progression of HCC remains unknown. Methods: The mRNA and protein expression of THRSP was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Endoplasmic Reticulum Stress and Disease
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34093825
DOI: 10.7150/jca.51657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Downregulation of THRSP Promotes Hepatocellular Carcinoma Progression by Triggering ZEB1 Transcription in an ERK-dependent MannerPMID 34093825Read ↗

THRSP identified as a potential hepatocellular carcinoma marker by integrated bioinformatics analysis and experimental validationSemantic proximity Read ↗

The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expressionSemantic proximity Read ↗

TOX3 drives hepatocellular carcinoma progression by suppressing the p53-p21-Rb pathwaySemantic proximity Read ↗

LpCat1 Promotes Malignant Transformation of Hepatocellular Carcinoma Cells by Directly Suppressing STAT1Semantic proximity Read ↗

Long noncoding RNA PVT1 promotes hepatocellular carcinoma progression through regulating miR-214Semantic proximity Read ↗

IGFBP2 upregulates ZEB1 expression and promotes hepatocellular carcinoma progression through NF-κB signaling pathwaySemantic proximity Read ↗

Squalene epoxidase promotes hepatocellular carcinoma development by activating STRAP transcription and TGF-β/SMAD signalingSemantic proximity Read ↗

CRSP8 promotes thyroid cancer progression by antagonizing IKKα-induced cell differentiationSemantic proximity Read ↗

Decreased expression of thyroid hormone receptor beta (THRB) indicates a poor prognostic factor for liver cancerSemantic proximity Read ↗

Squalene epoxidase promotes hepatocellular carcinoma development by activating STRAP transcription and TGF‐β/SMAD signallingSemantic proximity Read ↗

CSTB accelerates the progression of hepatocellular carcinoma via the ERK/AKT/mTOR signaling pathwaySemantic proximity Read ↗

Relationship of Signaling Pathways between RKIP Expression and the Inhibition of EMT-Inducing Transcription Factors SNAIL1/2, TWIST1/2 and ZEB1/2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.