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Exercise, APOE Genotype, and Testosterone Modulate Gut Microbiome-Cognition Associations in Prostate Cancer Survivors.

Genes - 16 Dec 2025

Raber Jacob, O'Niel Abigail, Kasschau Kristin D, Pederson Alexandra, Robinson Naomi, Guidarelli Carolyn, Chalmers Christopher, Winters-Stone Kerri, Sharpton Thomas J

Abstract excerpt

Background: Men treated with androgen deprivation therapy (ADT) for prostate cancer are at risk for cognitive decline. Patient genetics and endocrine state may shape gut microbiome features that relate to cognition. Methods: We studied a subsample of 79 prostate cancer survivors with prior ADT exposure previously enrolled in a randomized controlled exercise trial comparing three training modalities (strength...

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Identifiers

PMID: 41465180
DOI: 10.3390/genes16121507
PMCID: PMC12732690

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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