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Article

Sequential Phage Delivery Can Outperform Cocktails by Delaying Cross-Resistance Evolution.

Viruses - 25 Mar 2026

Stuart Elizabeth C, Meyer Justin R

Abstract excerpt

Antimicrobial resistance has renewed interest in bacteriophage therapy, yet bacterial evolution frequently undermines treatment efficacy. Combination phage therapy is commonly implemented as simultaneous phage cocktails, but whether this is optimal remains in question. Here, we experimentally compared simultaneous versus sequential administration of two phages, an evolved λ called 'λtrn' and T2, on Escherichia...

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PMID: 42043193
DOI: 10.3390/v18040404
PMCID: PMC13119524

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