Article
Association of Salpingectomy With Delayed Oophorectomy Versus Salpingo-oophorectomy With Quality of Life in BRCA1/2 Pathogenic Variant Carriers: A Nonrandomized Controlled Trial.
JAMA oncology - 1 Aug 2021
Steenbeek Miranda P, Harmsen Marline G, Hoogerbrugge Nicoline, de Jong Marieke Arts, Maas Angela H E M, Prins Judith B, Bulten Johan, Teerenstra Steven, van Bommel Majke H D, van Doorn Helena C, Mourits Marian J E, van Beurden Marc, Zweemer Ronald P, Gaarenstroom Katja N, Slangen Brigitte F M, Brood-van Zanten Monique M A, Vos M Caroline, Piek Jurgen M J, van Lonkhuijzen Luc R C W, Apperloo Mirjam J A, Coppus Sjors F P J, Massuger Leon F A G, IntHout Joanna, Hermens Rosella P M G, de Hullu Joanne A
Abstract excerpt
IMPORTANCE: Most women with a BRCA1/2 pathogenic variant undergo premature menopause with potential short- and long-term morbidity due to the current method of ovarian carcinoma prevention: risk-reducing salpingo-oophorectomy (RRSO). Because the fallopian tubes play a key role in ovarian cancer pathogenesis, salpingectomy with delayed oophorectomy may be a novel risk-reducing strategy with benefits of delaying...
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