Article
The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature.
Oncotarget - 13 Oct 2015
Díaz-Beyá Marina, Brunet Salut, Nomdedéu Josep, Pratcorona Marta, Cordeiro Anna, Gallardo David, Escoda Lourdes, Tormo Mar, Heras Inmaculada, Ribera Josep Maria, Duarte Rafael, de Llano María Paz Queipo, Bargay Joan, Sampol Antonia, Nomdedeu Meritxell, Risueño Ruth M, Hoyos Montserrat, Sierra Jorge, Monzo Mariano, Navarro Alfons, Esteve Jordi
Abstract excerpt
Long non-coding RNAs (lncRNAs) are deregulated in several tumors, although their role in acute myeloid leukemia (AML) is mostly unknown.We have examined the expression of the lncRNA HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) in 241 AML patients. We have correlated HOTAIRM1 expression with a miRNA expression profile. We have also analyzed the prognostic value of HOTAIRM1 expression in 215 intermediate-risk...
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